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Molecular cloning and functional expression of a mu-opioid receptor from rat brain

The medication increases the release of insulin from the pancreas in response to high blood sugar levels

All surgical and experimental procedures regarding animal primary cell lines followed Dutch and European laws and guidelines, and were approved by the Centrale Commissie Dierproeven (CCD) (AVD11000202115663)

GHR is widely expressed in GH target cells, which can combine with GH to activate diverse signal cascades, including mitogenic signaling through Janus kinase (JAKs) signal transducers and activators of transcription (STATs) (Vanderkuur et al., 1997), phosphoinositide-3-kinase (PI3K)/Protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) pathways (Hayashi and Proud, 2007) and phospholipase C (PLC)/Protein kinase C (PKC) ( GHR will further disrupt the normal development of the organism and lead to dwarfism phenotype in a wide array of species (Lin et al., 2018)

FOR LABORATORY RESEARCH USE ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE